Food, Fitness & Pharma

In society and the social setting, it is known that most strategies employed to make people change behaviour have little or no impact. We need to known more about why people act and choose as they do and which interventions are effectfull.

Expected outcome of the research is development of new platforms for optimizing public and private regulations taking ethical issues into account, novel knowledge on factors influencing everyday lifestyle and health-related habits and exploration of the effect of social, psychological and societal methods and tools for reducing overweight.

The research will have impact by offering new preventive measures for the individual and society that are socially and ethically robust and could lead to new social psychological tools for a more effective, diverse and personalised approach in addressing overweight relevant for both the private and public sector.

Projects within Social Sciences and Humanities

Eating practices: Social and cultural aspects of hunger and satiety
Overall aim: Conceptions, understandings and everyday practices with respect to bodily signals and sensations related to appetite, hunger, satiety, and eating are analysed in different population groups, defined according to social background and physiological parameters.

Involved partners: Professors Lotte Holm, Gertrud Pfister, Thorkild I.A. Sørensen and Sten Madsbad and Associate Professor Laila Ottesen
PhD students: Bodil Just Christensen and Line Hillersdal    

Changing discourses and strategies in the fight against life-style related diseases
Overall aim: The project will analyse and discuss how the notion of life-style related diseases has developed historically and how it links to strategies to prevent and cure such diseases in order to identify ethical, social and health political dilemmas underlying contemporary attempts to fight life-style diseases. The project will provide a research based input to the public debate and on how to develop preventive health strategies that are efficient, medically responsible, increase equity and respect towards the autonomy of citizens, and thus qualify the basis for future decisions about policies and technologies.

Involved partners: Professors Peter Sandøe and Signild Vallgårda and Associate Professor Jesper Lassen and Lene Koch., Associate Professor

(Un)healthy bodies – health discourses and physical (in)activity among Danish adults
Overall aim: Activity patterns in different population groups are identified and analysed in relation to different understandings of health discourses, different sport experiences and attitudes towards physical activity as well as eating practices.

Involved partners: Professors Gertrud Pfister, Lotte Holm and Thorkild I.A. Sørensen and Associate Professor Laila Ottesen.
PhD student: Stine Frydendal Nielsen

Public and market regulation in the fight against life-style diseases – Opportunities and barriers
Overall aim: The effect of various regulatory measures on the implementation of public health policies related to life-style diseases are analysed and it is assessed how regulatory measures can best be used to support such public health policies.

Involved partners: Associate Professor Karsten Ronit, Professor Mette Hartlev and Senior Researcher Jørgen Dejgård Jensen.

Social-Psychological Interventions and Experiments for Effective Life Style Changes
Overall aim: The effectiveness of social-psychological intervention methods for life style changes is evaluated through randomised clinical trials testing rival and/or combined hypotheses concerning the merit of biological and social interventions.

Involved partners: Assistant Professor Niels Viggo Hansen, Professors Bo Jacobsen, Thomas Mandrup-Poulsen, Bente Klarlund Pedersen, Lars O. Dragsted, Sten Madsbad, Lotte Holm and Associate Professor Jesper Lassen.

The challenge/background of the initiative

The occurrence of lifestyle diseases such as obesity, diabetes and related cardiovascular and musculoskeletal disorders has increased dramatically over the last couple of decades. This world-wide epidemic has evolved and is recognized as one of the top global public health challenges, with staggering social and economical consequences.

The reasons for this are only partly known, but it appears to be related mainly to a general change in lifestyle towards poor eating habits and lack of physical activity, combined with genes predisposing for these diseases.

The aim of the initiative

Through the UNIK-FFP we aimed at identifying and understanding the interrelated environmental, genetic and epigenetic causes of obesity, diabetes and associated lifestyle diseases.

The ambition was to develop new means for preventing and curing these conditions including better, health-promoting food; optimal fitness programs; novel and efficient regimens for changing people’s lifestyle; and new and better pharmaceuticals.

This ambition was pursued using a cross disciplinary approach, bringing together world class scientific competences within food technology, nutrition, GI-tract physiology and endocrinology, genetics, epidemiology, immunology, systems biology, molecular pharmacology and drug discovery as well as sociological, psychological and economical sciences.

Major questions investigated by the initiative

Mapping of the ‘hormone cocktail’ responsible for the fast ‘cure’ of type 2 diabetes and the sustained weight loss following gastric bypass surgery. Can this be induced by food or mimicked by a drug?
Answered by the research line on Food, Gut Hormones, and Pharma

Why is fitness healthy – and much more than ‘burning off calories’? And how much is enough?
Answered by the research line on Fitness and Muscles

Why do we stick to ‘unhealthy habits’? And which changes in the environment will make our society healthier?
Answered by the research line on Social Sciences and Humanities.

How does our genetic background – the ‘cards that we have on our hands’ - make us particular susceptible to particular aspects of lifestyle (fat, sugar, inactivity etc )
Answered by the research line on Genetics and Epidemiology

Download organisation diagram for UNIK - Food, Fitness & Pharma

The Danish consultation process

To combat the increasing challenge of obesity, a Danish consultation process was initiated in the spring 2011. The purpose of the consultation process was to identify key research challenges, opportunities and priorities for Denmark and Europe in the field of obesity research in this decade, by mobilizing the strong Danish research initiatives and groups in the field of obesity and related research areas.

The ambition of the process was to explore and illustrate how the challenge of obesity can be met by cross-disciplinary research approaches in close collaboration between scientists and stakeholders; and how investment in obesity research will pave the way for societal and industrial innovation. The consultation process addressed the full specter of health promotion, prevention, diagnostics and treatment in the field of obesity.

Outcome of the Danish consultation process

The Danish consultation process has resulted in two documents - a report with a broad range of research ideas, based on inputs from leading researchers in multiple disciplines and a summary document that sums up the process and the main priorities.

Download full report of the Danish consultation process

Download one page summary of the Danish consultation process  

Key conclusions from the Danish input on obesity research towards 2020

• Obesity research for the next century should pave the way for:
• Sustainable messages on healthy choices and complementary technologies and approaches to support the consumer.
• Healthy food products and novel concepts for physical activity which are accepted, attractive and chosen by the consumers.
• Early diagnostic and target intervention for individuals prone to develop obesity and related diseases.
• Ways to avoid stigmatization and counterproductive reactions of regulations, recommendations, and interventions aiming at tackling obesity.
• Tailor-made pharmaceutical treatment regimes and novel drugs, with minimal adverse effects.
• Platforms for monitoring and predicting obesity, supporting and follow implementation, prevention and treatment actions.

Major potentials for investments in obesity research:

• Markers of susceptibility obesity-related diseases, refining phenotypic characterization and reclassification of obesity.
• Addressing adverse effects and dilemmas in classifying ’high risk’ individuals towards implementing a ‘tailor-made’ approach.
• Mapping social and societal factors complicating the healthy lifestyles and develop novel real life interventions and exploring potentials of ICT in optimizing interventions from individual through population level.
• Diet composition and dietary recommendations supported by novel food products.
• Follow-up of existing ageing European cohort incl. updated phenotyping, social epidemiology data and biological samples
• Novel interdisciplinary approaches to addressing the role of the brain in obesity, including gut- brain signalling, response to physical activity, genetic factors and candidate drug targets.
• Animal models with high translational potential in terms of genetics, physiology, behaviour, obesity and co-morbidities.
  
  

The process 

The report was created by bringing together more than 50 representatives of the Danish research groups involved in obesity research at a workshop hosted by The University of Copenhagen in August 2011.

The workshop was further attended by the leaders of the larger German research initiatives addressing obesity and by Professor Jean-Michel Oppert, President of EASO (the European Association for the Study of Obesity), MEP Christel Schaldemose the European Parliament, the Danish Agency for Science, Technology and Innovation, the Capital Region of Denmark and the Deans of the faculty of Health Sciences, University of Copenhagen.

The Danish consultation process was followed up by a workshop in Germany in December 2011 and a strategic conference in Brussels early 2012. The conference will be convened by EASO and hosted by DG Research.

These initiatives are to provide expert recommendations for the European Commission on the importance and exact role of obesity related research for the future. The basis for further bi-lateral synergies and liaison between the Danish and German research initiatives on obesity are further explored and strengthened.

Download the German Strategy Paper for tackling obesity in HORIZON 2020

EASO conference “From biology to society - what message can obesity research deliver to policy makers?“ - See Program and presentations

France ARP PROBS

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Social Sciences and Humanities contribution to tackle the Obesity Epidemic

In January 2013, a workshop on Social Sciences and Humanities (SSH) contribution to tackle obesity marked the beginning of a broader initiative focusing on the challenges and potentials in transdisciplinary obesity research towards 2020.

To tackle the challenge of obesity, we have to involve multiple scientific disciplines ranging from biomedicine and natural science to social sciences and humanities (SSH). This stands clear following the conference “From biology to society - what message can obesity research deliver to policy makers?” organized by the European Association for the Study of Obesity (EASO) in February 2012.

To create the best starting point for effective transdisciplinary collaborations, and to meet the expectations outlined in Horizon 2020, there was a need for a platform gathering the different disciplines constituting social sciences and humanities research to explore, how SSH between disciplines and in collaboration with the natural sciences can best contribute in finding solutions towards tackling the obesity epidemic. The SSH-initiative aimed at creating this platform across Europe.

The aims of the SSH initiative were:

• to deliver new insight on the challenges, potentials and priorities in obesity research though events and workshops
• to establish new and strengthen existing networks of European researchers within the SSH research area of obesity for forthcoming research collaborations
• to showcase the high potential in addressing obesity as a societal challenge approached through transdisciplinary practices deeply integrating researchers from social sciences and humanities.
  
  

Download the concluding report for online viewing (PDF)

Download the executive summary for the social sciences ans humanities workshop (PDF)

Potential impact of SSH obesity research

Social Sciences and Humanities (SSH) research addresses obesity in a different way than the natural and health sciences, and therefore deliver other kinds of outcomes and impact that are more contextually specific integrating the actions of humans.

Some of the concrete outcomes and impact from investing in and collaborating across SSH obesity research would be – but not limited to – the likes of the following:

The possibility to better address the actions of humans

SSH research addresses obesity in a different way than the natural and health sciences. It addresses obesity from the perspective of the human world – consisting of culturally-formed individuals, populations, societies, nations, communities, social groups, and organisations. Human beings possess agency; they attribute meaning to their actions; they create ideas about the world that guide their actions, and they produce and react to the environments in which they live. This produces contingency – not natural laws.

Daily habits and “cures”

The daily habits and concerns or practical understandings and orientations associated with the development of obesity may vary considerably between men and women, children and adults, social classes, and member states, which means that policies and services that proved effective in one national, regional, or socio-economic setting may not work in settings where institutional frameworks or economic conditions are different. Social sciences and humanities can help produce valid evidence of the specific conditions for causes, problems, and “cures” in various contexts.

A new understanding of obesity as a complex phenomenon

Social sciences and humanities most often produce results that are contextually specific. This can help provide a more precise understanding of obesity in relation to population groups, communities, cultures, or social classes. Findings on the causes of obesity or how obesity can best be addressed will always vary according to the specific context.

Long term impact of focusing on SSH in obesity research:

• To prepare the European obesity research community for the forthcoming EU framework programme Horizon 2020, which will address societal challenges through research.
• To establish and strengthen the network of researchers in social sciences and humanities with an interest, capacity, and experience in obesity research.
• To create a forum for discussion that aims to shape future obesity research.
• To facilitate the creation of new transdisciplinary collaborations in obesity research across Europe.
• To address and support breaking down barriers in transdisciplinary research such as few obvious points of collaboration, the lack of incentives to initiate collaboration, the differences

Members of the Executive Board

• Dean, Professor, Ulla Wewer, (Chair of the Executive Board, Dean of the Faculty of Health Sciences)
• Professor Thue W. Schwartz, Department of Neurosciences and Pharmacology, Faculty of Health Sciences, (Head of the UNIK)
• Professor Lars O. Dragsted, Department of Human Nutrition, Faculty of Life Sciences
• Professor Lotte Holm, Department of Human Nutrition, Faculty of Life Sciences
• Professor Kitt F. Petersen, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA (Chair of the Scientific Advisory Board)
• Secretary of the board: Research Manager Camilla Verdich

Deputies

• Professor Jens J. Holst, Department of Biomedical Sciences, Faculty of Health Sciences, (Deputy for Thue W. Schwartz)
• Professor Leif H. Skibsted, Department of Food Sciences, Faculty of Life Sciences, (Deputy for Lars O. Dragsted)
• Professor Mette Hartlev, WELMA - Center, Faculty of Law, (Deputy for Lotte Holm)
  
  

Members of the UNIK Scientific Advisory Board

• Professor Kitt F. Petersen, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA
• Professor Gerald I. Shulman, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, USA
• Professor Michael Stumvoll, IFB Adiposity Diseases, Faculty for Medicine, Medizinische Klinik III, University of Leipzig, Germany
• Professor Grahame Hardie, Department of Molecular Physiology, Dundee University, Scotland
  
• Professor Anne Murcott, Institute for Science & Society, Faculty of Social Sciences, Law and Education, Nottingham University
• Professor Alfons G. Voragen, Laboratory of Food Chemistry, University of Wageningen, The Netherlands
• Professor Ruth Loos, Director of the Genetics of Obesity and Related Metabolic Traits Program, in the Charles R. Bronfman Institute of Personalized Medicine, New York, US

Senior scientists

Gastro-Intestinal tract

Anders Sjödin, Associate Professor
Department of Nutrition, Exercise and Sports

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Arne Astrup, Professor
Department of Nutrition, Exercise and Sports

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Axel Kornerup Hansen, Professor
Department of Veterinary Disease Biology

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Birgitte Holst, Professor with special responsibilities
Department of Neuroscience and Pharmacology

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Finn Kvist Vogensen, Associate Professor
Department of Food Science

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Hans Bräuner-Osborne, Professor
Department of Medical Chemistry

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Harald S Hansen, Professor
Department of Pharmacology and Pharmacotherapy

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Jens Juul Holst, Professor
Department of Biomedical Sciences

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John Nielsen, Professor
Department of Drug Design and Pharmacology

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Lars O. Dragsted, Professor
Department of Nutrition, Exercise and Sport

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Leif Horsfelt Skibsted, Professor
Department of Food Science 

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Mette Rosenkilde, Professor
Department of Neuroscience and Pharmacology

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Per Torp Sangild, Professor
Department of Nutrition, Exercise and Sports

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Sten Madsbad, Professor
Department of Clinical Medicine 

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Susanne Bügel, Associate Professor
Department of Nutrition, Exercise and Sports

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Søren Balling Engelsen, Professor
Department of Food Science

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Thomas Mandrup-Poulsen, Professor
Department of Biomedical Sciences

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Thue W Schwartz, Professor
Department of Neuroscience and Pharmacology

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Fitness and Muscle

Annemarie Thuri Kristensen, Professor
Department of Small Animal Clinical Sciences

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Bente Kiens, Professor
Department of Nutrition, Exercise and Sport

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Bente Klarlund Pedersen, Professor
Department of Clinical Medicine 

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Bente Stallknecht, Associate Professor
Department of Biomedical Sciences

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Charlotte Bjørnvad, Professor
Department of Veterinary Clinical and Animal Sciences

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Erik Richter, Professor
Department of Nutrition, Exercise and Sport

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Flemming Dela, Professor
Department of Biomedical Science

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Jørgen Wojtaszewski, Professor
Department of Nutrition, Exercise and Sport

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Thorkil Ploug, Associate Professor
Department of Biomedical Sciences

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Social Sciences and Humanities

Bo Jacobsen, Professor
Department of Sociology

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Gertrud Pfister, Professor
Department of Nutrition, Exercise and Sports

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Jesper Lassen, Associate Professor
Department of Food and Resource Economics

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Jørgen Dejgård Jensen, Senior Researcher
Department of Food and Resource Economics

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Karsten Ronit, Associate Professor
Department of Political Science

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Laila Ottesen, Associate Professor
Department of Nutrition, Exercise and Sports

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Lene Koch, Associate Professor
Department of Public Health

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Lotte Holm, Professor
Department of Food and Resource Economics

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Mette Hartlev, Professor
WELMA - Center

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Niels Viggo Hansen, Assistant Professor
Department of Sociology

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Peter Sandøe, Professor
Department of Large Animal Sciences

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Signild Vallgårda, Professor
Department of Public Health

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Genetic Epidemiology

Anne Tjønneland, Affiliated Professor
Department of Public Health

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Kim Overvad, Affiliated Professor
Department of Public Health

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Merete Fredholm, Professor
Department of Basic Animal and Veterinary Sciences

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Oluf Borbye Pedersen, Professor
Department of Biomedical Sciences

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Thorkild IA Sørensen, Professor
Department of Public Health

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Torben Hansen, Professor
The Novo Nordisk Foundation Center for Basic Metabolic Research

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Special UNIK Core Initiative

Birgitte Holst, Professor
Department of Neurosciences and Pharmacology

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Lars O. Dragsted, Professor
Department of Nutrition, Exercise and Sports

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Niels Tommerup, Professor
Department of Cellular and Molecular Medicine 

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Sten Madsbad, Professor
Department of Clinical Medicine

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PhD students 

Gastro-intestinal theme

• Andreas Vegge
• Carsten Dirksen
• Cathrine Laustrup Møller
• Christoffer Clemmensen
• Berit Svendsen
• Frederik Hansen
• Gözde Gürdeniz
• Helle Adser Hassing
• Jakob Bondo Hansen
• Jan Stanstrup
• Julie Berg Schmidt
• Karen Kleberg Hansen
• Niels Wellner
• Nils Bruun Jørgensen
• Maja Storm Engelstoft
• Malene Wibe Poulsen
• Merete Ellekilde
• Mette Skau Mikkelsen
• Monika Bak
• Sabine Ibrügger
• Siv Hesse Jacobsen
• Thi Ai Diep
  
  

Fitness and muscle theme

• Andreas Børsting Jordy
• Andreas Vigelsø Hansen
• Kim Anker Sjøberg
• Kirstine Nyvold Bojsen-Møller
• Louise D Høeg
• Lykke Sylow
• Mads Rosenkilde
• Martin Gram
• Michala H Reichkendler
• Peter Hjorth Albers
• Pernille Landrock Auerbach
• Søren Nielsen

Social Sciences and Humanities

• Bodil Just Christensen
• Line Hillersdal
• Stine Frydendal Nielsen
  
  

Genetic Epidemiology:

• Benjamin Rokholm
• Karina Banasik
• Mikkel Z. Ankarfeldt
• Sofus Larsen
• Teresa Ajslev

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Research Coordination Unit

Camilla Verdich, Research Coordinator
cave@sund.ku.dk 

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The list of publications was last updated in June 2015, and only include publications accepted before that date.

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Publications within Gastro-intestinal theme

Bariatric Surgery 

Resolution of type 2 diabetes after bariatric surgery:

• Bariatric surgery-Effects on obesity and related co-morbidities. Svane M and Madsbad S. Current Diabetes Reviews, 2014.
• Medicinske komplikationer i forbindelse med bariatrisk kirurgi. Madsbad S. Ugeskrift for læger, Leder 2014; 176: 1449.
• Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery. Madsbad S, Dirksen C, Holst JJ. Lancet Diabetes Endocrinol. 2014 Feb.
• Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. Bojsen-Møller KN, Dirksen C, Jørgensen NB, Jacobsen SH, Serup AK, Albers PH, Hansen DL, Worm D, Naver LS, Kristiansen VB, Wojtaszewski JFP, Kiens B, Holst JJ, Richter EA, Madsbad S. Diabetes. 2013 Nov 15.
• Effects of Roux-en-Y gastric bypass on fasting and postprandial levels of the inflammatory markers YKL-40 and MCP-1 in patients with type 2 diabetes and glucose tolerant subjects. Thomsen SB, Rathcke CN, Jørgensen NB, Madsbad S, Vestergaard H. J Obes. 2013;2013:361781
• Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration one year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: A case report. Carsten Dirksen, Siv H Jacobsen, Kirstine N Bojsen-Møller, Nils B Jørgensen, Lars S Naver, Lisbeth E Hvolris, Dorte Worm, Sten Madsbad, Jens J Holst, Dorte L Hansen. Obesity Research & Clinical Practice 2013; 7: e235-320.
• Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals. Jacobsen SH, Bojsen-Møller KN, Dirksen C, Jørgensen NB, Clausen TR, Wulff BS, Kristiansen VB, Worm D, Hansen DL, Holst JJ, van Hall G, Madsbad S. Diabetologia. 2013 Oct.
• Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes. Jørgensen NB, Dirksen C, Bojsen-Møller KN, Jacobsen SH, Worm D, Hansen DL, Kristiansen VB, Naver L, Madsbad S, Holst JJ. Diabetes. 2013 Sep.
• Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Dirksen C, Jørgensen NB, Bojsen-Møller KN, Kielgast U, Jacobsen SH, Clausen TR, Worm D, Hartmann B, Rehfeld JF, Damgaard M, Madsen JL, Madsbad S, Holst JJ, Hansen DL. Int J Obes, 2013
• Increased hepatic insulin clearance after Roux-en-Y gastric bypass. Bojsen-Møller KN, Dirksen C, Jørgensen NB, Jacobsen SH, Hansen DL, Worm D, Naver L, Kristiansen VB, Holst JJ, Madsbad S. J Clin Endocrinol Metab. 2013 Jun.
• Fast pouch emptying, delayed small intestinal transit, and exaggerated gut hormone responses after Roux-en-Y gastric bypass. Dirksen C, Damgaard M, Bojsen-Møller KN, Jørgensen NB, Kielgast U, Jacobsen SH, Naver LS, Worm D, Holst JJ, Madsbad S, Hansen DL, Madsen JL. Neurogastroenterol Motil, 2013
• Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Jacobsen SH, Olesen SC, Dirksen C, Jørgensen NB, Bojsen-Møller KN, Kielgast U, Worm D, Almdal T, Naver LS, Hvolris LE, Rehfeld JF, Wulff BS, Clausen TR, Hansen DL, Holst JJ, Madsbad S. Obes Surg, 2012
• Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass, Dirksen C, Jørgensen NB, Bojsen-Møller KN, Jacobsen SH, Hansen DL, Worm D, Holst JJ, Madsbad S. Diabetologia, 2012
• Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with type 2 diabetes and normal glucose tolerance, Jorgensen NB, Jacobsen SH, Dirksen C, Bojsen-Moller KN, Naver L, Hvolris L, Clausen TR, Wulff BS, Worm D, Hansen DL, Madsbad S, Holst JJ. Am J Physiol Endocrinol Metab, 2012
• Gastric bypass and duodenal and gastric feeding: a comment to Hansen et al. Jorgensen NB, Dirksen C, Holst JJ, Madsbad S. Am J Physiol Gastrointest Liver Physiol, 2011
• Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report. Dirksen C, Hansen DL, Madsbad S, Hvolris LE, Naver LS, Holst JJ, Worm D.. Diabetes Care, 2010
• Kirurgisk behandling af type 2 diabetes? Stine Chabert, Dorte Lindqvist Hansen, Thomas Almdal, Flemming Bendtsen, Inge Nordgaard, Lisbeth Edvardsen Hvolris, Jens J Holst, Lars Naver og Sten Madsbad. Ugeskrift For Læger. 2009; 171: 615-18. 

Pig models to study nutrition-mediated gut-brain peptide signalling:

• Animal models of infant short bowel syndrome: Translational relevance and challenges. Sangild PT, Ney DM, Sigalet DL, Vegge A, Burrin DG. American Journal of Physiology Gastrointestinal and Liver Physiology (in press 2014)
• Acute effects of the glucagon-like peptide 2 analogue, teduglutide, on intestinal adaptation in short bowel syndrome. Thymann T, Stoll B, Mecklenburg L, Burrin DG, Vegge A, Qvist N, Eriksen T, Jeppesen PB, Sangild PT. . J Pediatr Gastroenterol Nutr. 2014 Jun.
• Prematurity Reduces Functional Adaptation to Intestinal Resection in Piglets. Aunsholt L, T Thymann, N Qvist, D Sigalet, S Husby, PT Sangild. JPEN J Parenter Enteral Nutr. 2014 Mar 31
• Parenteral lipids and partial enteral nutrition affect hepatic lipid composition but have limited effects on formula-induced necrotizing enterocolitis in preterm piglets. Vegge A, Thymann T, L Lauritzen, SB Bering, B Wiinberg, PT Sangild. Clin Nutr. 2014 Mar 19
• Ileal transposition surgery: Gut morphology and endocrine cell numbers in the UCD-T2DM rat. Regulatory Peptides. Hansen CF, E Vassiliadis, N Vrang, P Sangild, B Cummings, P Havel and J Jelsing. Regul Pept. 2014 Feb 7
• Laparoscopic Roux-en-Y gastric bypass in super obese Göttingen minipigs. Birck MM, Vegge A, Støckel M, Gögenur I, Thymann T, Hammelev KP, Sangild PT, Hansen AK, Raun K, von Voss P, Eriksen T. Am J Transl Res. 2013 Sep.
• Invited review: the preterm pig as a model in pediatric gastroenterology. Sangild PT, Thymann T, Schmidt M, Stoll B, Burrin DG, Buddington RK. J Anim Sci. 2013 Oct
• Bovine Colostrum to Children With Short Bowel Syndrome: A Randomized, Double-Blind, Crossover Pilot Study. Aunsholt L, Jeppesen PB, Lund P, Sangild PT, Ifaoui IB, Qvist N, Husby S. JPEN J Parenter Enteral Nutr. 2012
• Novel insight into the distribution of L-cells in the rat intestinal tract. Hansen CF, Vrang N, Sangild PT, Jelsing J. Am J Transl Res, 2013
• Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats. Hansen CF, Bueter M, Theis N, Lutz T, Paulsen S, Dalbøge LS, Vrang N, Jelsing J. PLoS one, 2013
• Glucagon-Like Peptide-2 Induces Rapid Digestive Adaptation Following Intestinal Resection in Preterm Neonates. Vegge A, Thymann T, Lund P, Stoll B, Bering SB, Hartmann B, Jelsing J, Qvist N, Burrin DG, Jeppesen PB, Holst JJ, Sangild PT. Am J Physiol Gastrointest Liver Physiol, 2013
  
  

Food and GI Tract 

Soluble plant fibres from foods and their metabolic/satiety signalling:

• Extracted oat and barley β-glucans do not affect cholesterol metabolism in young healthy adults. Ibrügger S., Kristensen, M., Poulsen, M.W., Mikkelsen, M.S., Ejsing, J., Jespersen, B.M., Dragsted, L.O., Engelsen, S.B., Bügel, S (2013) J. Nutr. 143 (10), 1579-1585
• Molecular structure of large-scale extracted β-glucan from barley and oat: Identification of a significantly changed block structure in a high β-glucan barley mutant. Mikkelsen MS, Jespersen BM, Larsen FH, Blennow A, Engelsen SB. Food Chem, 2013

Effects of intravenous infusions of gut hormones on energy expenditure and appetite regulation in healthy obese subjects:

• Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure and appetite in overweight men. Schmidt JB1, Gregersen NT, Pedersen SD, Arentoft JL, Ritz C, Schwartz TW, Holst JJ, Astrup A, Sjödin A. Am J Physiol Endocrinol Metab. 2014 Apr 15.

Gut microbiota and low-grade inflammation in Type 2 diabetes:

• Insulin Detemir treatment in diabetic cats in a practice setting. Hoelmkjaer KM, Spodsberg EM, Bjornvad CR. J Feline Med Surg. 2014 Jun 17. pii: 1098612X14538642. Epub ahead of printing
• Obesity and sex influence insulin resistance and total and multimer adiponectin levels in adult neutered domestic shorthair client-owned cats. Bjornvad CR, Rand JS, Tan HY, Jensen KS, Rose FJ, Armstrong PJ, Whitehead JP. Domest Anim Endocrinol. 2014 Apr;47:55-64
• 2-Heptyl-Formononetin Increases Cholesterol andInduces Hepatic Steatosis in Mice. Andersen C, Schjoldager J, Tortzen CG, Vegge A, Hufeldt MR, Skaanild MT, Vogensen FK, Kristiansen K, Hansen AK, and Nielsen J. BioMed Research International, 2013
• Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, Heller RS, Nielsen AØ, Størling J, Baeyens L, Anker-Kitai L, Qvortrup K, Bouwens L, Efrat S, Aalund M, Andrews NC, Billestrup N, Karlsen AE, Holst B, Pociot F, Mandrup-Poulsen T Cell Metab, 2012
• Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Hansen CH, Krych L, Nielsen DS, Vogensen FK, Hansen LH, Sørensen SJ, Buschard K, Hansen AK Diabetologia, 2012
• Understanding adiponectin in dogs and cats: a work in progress. Verkest KR, Bjornvad CR. Vet J. 2012 Jul;193(1):4-5.
• Patterns of early gut colonization shape future immune responses of the host, Hansen CH, Nielsen DS, Kverka M, Zakostelska Z, Klimesova K, Hudcovic T, Tlaskalova-Hogenova H, Hansen AK. PLoS One, 2012.
• Manipulation of the gut microbiota in C57BL/6 mice changes glucose tolerance without affecting weight development and gut mucosal immunity, Bech-Nielsen GV, Hansen CH, Hufeldt MR, Nielsen DS, Aasted B, Vogensen FK, Midtvedt T, Hansen AK. Res Vet Sci,2011

Formation of Advanced Glycation End Products (AGE) in food and in the GI-tract:

• Free radical processes in non-enzymatic browning of glucose and lysine. Influence of temperature and unsaturated lipids. Rikke V. Hedegaard, Cecile Santos, Thoo Yin Yin & Leif H. Skibsted. J. Chem., 67, 2014, 805-812.
• Epicatechin and epigallocatechin gallate inhibit formation of intermediary radicals during heating of lysine and glucose. Yin, R.V. Hedegaard, L.H. Skibsted, M.L. Andersen. Food Chemistry. Volume 146, 1 March 2014
• Shelf-life of food powders R. V. Hedegaard and L. H. Skibsted Chapter 16 in “Handbook of food powders: Processes and properties” Edited by B Bhandari, N Bansal, University of Queensland, Australia, M Zhang, Jiangnan University, China and P Schuck, INRA, France.
• Oxidative stability and chemical safety of mayonnaise enriched with grape seed extract. Altunkaya A, Hedegaard RV, Harholt J, Brimer L, Gökmen V, Skibsted LH. Food Funct. 2013 Sep.
• Formation of Advanced Glycation End Products (AGEs) are Influenced by Lipids in Milk Powders. Liu L, Hedegaard R and Skibsted L. Australian Journal of Chemistry 2013 Jul.
• Formation of radicals during heating lysine and glucose in solution with an intermediate water activity. Jie Yin, Mogens L. Andersen, Marianne K. Thomsen, Leif H. Skibsted & Rikke V. Hedegaard. Free Rad. Res., 47, 2013, 643-650.
• Palatability and chemical safety of apple juice fortified with pomegranate peel extract. Dinçay A, Hedegaard R, Harholt J, Brimer L, Gökmen V and Skibsted L Food Function, 2013 Jul.
• Advanced glycation end products in food and their effects on health. Poulsen MW, Hedegaard RV, Andersen JM, de Courten B, Bügel S, Nielsen J, Skibsted LH, Dragsted LO. Food Chem Toxicol. 2013 Jul 16.
• Formation of radicals during heating lysine and glucose in solution with an intermediate water activity. Yin J, Andersen ML, Thomsen MK, Skibsted LH, Hedegaard RV. Free Radic Res. Epub 2013 Jun 28.
• Antioxidant capacity versus chemical safety of wheat bread enriched with pomegranate peel powder. Altunkaya A, Hedegaard RV, Brimer L, Gökmen V, Skibsted LH. Food Funct. 2013 Apr 30.
• Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. Thoo YY, Abas F, Lai OM, Ho CW, Yin J, Hedegaard RV, Skibsted LH, Tan CP. Food Chem, 2012

Metabolic signalling by Advanced Glycation End products (AGE) from foods:

• Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in human plasma.Bak, M.J.; Wewer Albrechtsen, N.J.; Pedersen, J.; Hartmann, B.; Christensen, M.; Vilsboll, T.; Knop, F.K.; Deacon, C.F.; Dragsted, L.O.; Holst, J.J. Eur J.Endocrinol. 170,4; 529-538(2014a)
• Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies. Bak, M.J., Albrechtsen, N.J.W., Pedersen, J., Knop, F., Vilsboll, T., Jørgensen, N.B., Hartmann, B., Deacon, C.F., Dragsted, L.O., Holst,J.J. Diabetes, Obesity and Metabolism (2014)
• Advanced glycation end products in food and their effects on health. Poulsen MW, Hedegaard RV, Andersen JM, de Courten B, Bügel S, Nielsen J, Skibsted LH, Dragsted LO. Food Chem Toxicol. 2013 Oct.
• Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. Poulsen MW, Bak MJ, Andersen JM, Monošík R, Giraudi-Futin AC, Holst JJ, Nielsen J, Lauritzen L, Larsen LH, Bügel S, Dragsted LO. Eur J Nutr. 2013 Aug.
• Consumption of a Diet Low in Advanced Glycation End products for 4 weeks Improves Insulin Sensitivity in Overweight Women. Mark AB, Poulsen MW, Andersen S, Andersen JM, Bak MJ, Ritz C, Holst JJ, Nielsen J, de Courten B, Dragsted LO, Bügel S. Diabetes Care. 2013 Aug.
• Convenient Synthesis of Nε-(Carboxymethyl)lysine, a Key Advanced Glycation End product Biomarker, Andersen JM, Hjelmgaard T, Dragsted LO and Nielsen J. Synlett, 2011
  
  

Pharma 

Characterization of the complete hormonal and chemo-sensor repertoire of the enteroendocrine system:

• Enteroendocrine cell types revisited. Engelstoft MS, Egerod KL, Lund ML, Schwartz TW. Curr Opin Pharmacol. 2013 Oct.
• GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Nøhr MK, Pedersen MH, Gille A, Egerod KL, Engelstoft MS, Husted AS, Sichlau RM, Grunddal KV, Poulsen SS, Han S, Jones RM, Offermanns S, Schwartz TW. 2013 Oct.
• A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Egerod KL, Engelstoft MS, Grunddal KV, Nøhr MK, Secher A, Sakata I, Pedersen J, Windeløv JA, Füchtbauer EM, Olsen J, Sundler F, Christensen JP, Wierup N, Olsen JV, Holst JJ, Zigman JM, Poulsen SS, Schwartz TW. Endocrinology, Dec 2012
• GPR119 as a fat sensor. Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Trends Pharmacol Sci. 2012 Jul.
• GPR39 deficiency is associated with pancreatic islet cell dysfunction, Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Ørskov C. Wierup N, Sundler F, Madsen OD and Schwartz TW. Endocrinology, 2009
• An enteroendocrine full package solution, Schwartz TW and Holst B. Cell Metab, 2010

Functional in vitro and in vivo characterization of entero-endocrine sensors of nutrients and food components as potential drug targets:

• Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop. Mokrosinski J, Frimurer TM, Sivertsen B, Schwartz TW, Holst B. J Biol Chem, 2012
• Unique interaction pattern for a functionally biased ghrelin receptor agonist, Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW, Beck-Sickinger AG, Holst B. J Biol Chem, 2011
• Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism. Petersen PS, Jin C, Madsen AN, Rasmussen M, Kuhre R, Egerod KL, Nielsen LB, Schwartz TW, Holst B. FASEB J, 2011
• In vivo characterization of high Basal signaling from the ghrelin receptor, Petersen PS, Woldbye DP, Madsen AN, Egerod KL, Jin C, Lang M, Rasmussen M, Beck-Sickinger AG, Holst B. Endocrinology, 2009

GI-tract derived lipid ligands controlling metabolism through enteroendocrine, pancreatic and CNS receptors:

• Classical endocannabinoid-like compounds and their regulation by nutrients. Kleberg K, Hassing HA, Hansen HS(2014)BioFactors, 40; 363-372.
• Role of anorectic N-acylethanolamines in intestinal physiology and satiety control with respect to dietary fat. Hansen HS (2014)Pharmacol Res, 86; 18-25.
• Identification of fatty acids as the dietary component involved in regulation of anorectic intestinal N-acylethanolamines. Diep TA, Madsen AN, Krogh-Hansen S, Al-Sabagh M, Al-Shahwani L, Holst B, Hansen HS (2014) PLoS ONE, 9, e100365
• N-acylation of phosphatidylethanolamine and its biological functions in mammals. Wellner N, Diep TA, Janfelt C, Hansen HS. Biochim Biophys Acta. 2013 Mar.
• Effect of diet on tissue levels of palmitoylethanolamide. Hansen HS, CNS Neurol Disord Drug Targets. 2013 Feb
• GPR119 as a fat sensor, Hansen HS, Rosenkilde MM, Holst JJ, Schwartz TW. Trends Pharmacol Sci, 2012
• Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS. Biochim Biophys Acta, 2011
• 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans, Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS. J Clin Endocrinol Metab, 2011
• Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss, Bennetzen MF, Wellner N, Ahmed SS, Ahmed SM, Diep TA, Hansen HS, Richelsen B, Pedersen SB. Int J Obes, 2011
• Dietary fat decreases intestinal levels of the anorectic lipids through a fat sensor,Diep TA, Madsen AN, Holst B, Kristiansen MM, Wellner N, Hansen SH, Hansen HS. FASEB J, 2011
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂, Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA. Pharmacol Rev, 2010
• Pitfalls in the sample preparation and analysis of N-acylethanolamines, Skonberg C, Artmann A, Cornett C, Hansen SH, Hansen HS. J Lipid Res, 2010
• The endocannabinoid system and its relevance for nutrition, Maccarrone M, Gasperi V, Catani MV, Diep TA, Dainese E, Hansen HS, Avigliano L. Annu Rev Nutr, 2010
• Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain. Hansen HS. Exp Neurol, 2010

The physiological role of the GPRC6A receptor:

• FXR is a molecular target for the effects of vertical sleeve gastrectomy. Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-Perez HE, Sandoval DA, Kohli R, Backhed F, Seeley RJ. Nature 2014.
• Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress. Ryan KK, Mul JD, Clemmensen C, Egan AE, Begg DP, Halcomb K, Seeley RJ, Herman JP, Ulrich-Lai YM. Psychoneuroendocrinology 2014;42:98-105
• Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor. Jacobsen SE, Norskov-Lauritsen L, Thomsen AR, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Brauner-Osborne H. J Pharmacol Exp Ther. 2013 Sep.
• The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor: From cloning to physiological function. Clemmensen C, Smajilovic S, Wellendorph P, Bräuner-Osborne H. Br J Pharmacol. 2013 Aug.
• Oral L-arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice. Clemmensen C, Smajilovic S, Smith EP, Woods SC, Bräuner-Osborne H, Seeley RJ, D'Alessio DA, Ryan KK. 2013 Aug.
• Promiscuous Seven Transmembrane Receptors Sensing L-a-amino Acids. Smajilovic S, Wellendorph P, Bräuner-Osborne H. Curr Pharm Des. 2013 Jul.
• Enhanced voluntary wheel running in GPRC6A receptor knockout mice. Clemmensen C, Pehmøller C, Klein AB, Ratner C, Wojtaszewski JF, Bräuner-Osborne H. Physiol Behav. 2013 Jun 13
• Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice. Clemmensen C, Smajilovic S, Madsen AN, Klein AB, Holst B, Bräuner-Osborne H. J Endocrinol, Feb 2013
• Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, Schubert K, Schöneberg T, Schaefer M, Krügel U, Smajilovic S, Bräuner-Osborne H, Baerwald C & Wagner U. Nat Commun, Dec 2012
• L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances. Clemmensen C, Madsen AN, Smajilovic S, Holst B, Bräuner-Osborne H. Amino Acids, 2012
• The L: -α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L: -arginine-induced insulin release. Smajilovic S, Clemmensen C, Johansen LD, Wellendorph P, Holst JJ, Thams PG, Ogo E, Bräuner-Osborne H. Amino Acids, 2012
• Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. Gloriam DE, Wellendorph P, Johansen LD, Thomsen AR, Phonekeo K, Pedersen DS, Bräuner-Osborne H. Chem Biol, 2011
• The emerging role of promiscuous 7TM receptors as chemosensors for food intake. Wellendorph P, Johansen LD, Bräuner-Osborne H. Vitam Horm, 2010

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Publications within Fitness and Muscle theme

Muscle and Gastro-intestinal tract interaction 

Gastrointestinal bypass, insulin sensitivity and mitochondrial function:

• Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass. Bojsen-Møller KN, Dirksen C, Jørgensen NB, Jacobsen SH, Serup AK, Albers PH, Hansen DL, Worm D, Naver L, Kristiansen V, Wojtaszewski JFP, Kiens B, Holst JJ, Richter EA, Madsbad S. Diabetes. 2013 Nov 15.
• Increased Hepatic Insulin Clearance after Roux-en-Y Gastric Bypass. Bojsen-Møller KN,Dirksen C, Jørgensen NB, Jacobsen SH, Hansen DL, Worm D, Naver L, Kristiansen VB, Holst JJ, Madsbad S. JCEM 2013; 98: 1066-71.
• Presentation abstract: Hepatic and Peripheral Insulin Sensitivity 1 week and 3 months after Roux-en-Y Gastric Bypass surgery in subjects with Type 2 Diabetes and Normal Glucose Tolerance. Bojsen-Møller KN et al. EASD conference, 2012
• Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass. Dirksen C, Jørgensen NB, Bojsen-Møller KN, Jacobsen SH, Hansen DL, Worm D, Holst JJ, Madsbad S. Diabetologia, 2012 

Linking muscle and gut signalling in metabolic syndrome:

• Effects of lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of glutamate and glycine in healthy humans, Ronan M. G. Berg,Sarah Taudorf, Damian M. Bailey, Carsten Lundby, Fin S. Larsen, Bente K. Pedersen, Kirsten Møller. APMIS, 2012
• Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle, Pedersen L, Olsen CH, Pedersen BK, Hojman P. Am J Physiol Endrocrinol Metab, 2012 
• Muscle Specific MicroRNAs are regulated by Endurance Exercise in Human Skeletal Muscle, Nielsen S, Scheele C, Yfanti C, Akerstrom TC, Nielsen AR, Pedersen BK, Laye MJ. J Physiol, 2010

Lipid-induced insulin resistance: reversibility by physical activity and susceptibility by aging?

• AMPK and insulin action--responses to ageing and high fat diet. Frøsig C, Jensen TE, Jeppesen J, Pehmøller C, Treebak JT, Maarbjerg SJ, Kristensen JM, Sylow L, Alsted TJ, Schjerling P, Kiens B, Wojtaszewski JF, Richter EA. PLoS One. 2013 May.
• LKB1 regulates lipid oxidation during exercise independently of AMPK. Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B. Diabetes. 2013 May.
• Adiponectin concentration is associated with muscle insulin sensitivity, AMPK phosphorylation, and ceramide content in skeletal muscles of men but not women. Høeg LD, Sjøberg KA, Lundsgaard AM, Jordy AB, Hiscock N, Wojtaszewski JF, Richter EA, Kiens B. J Appl Physiol (1985). 2013 Mar.
• Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle-Signaling Interaction at the Level of TBC1 Domain Family Member 4. Pehmøller C, Brandt N, Birk JB, Høeg LD, Sjøberg KA, Goodyear LJ, Kiens B, Richter EA, Wojtaszewski JF. Diabetes, 2012
• Regulation and limitations to fatty acid oxidation during exercise, Jacob Jeppesen et al. J Physiol, 2012. 
• Regulation and limitations to fatty acid oxidation during exercise. Jeppesen J and Kiens B. J Physiol, 2012
• Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle. Jeppesen J, Jordy AB, Sjøberg KA, Füllekrug J, Stahl A, Nybo L, Kiens B. PLoS One. 2012.
• Factors regulating fat oxidation in human skeletal muscle.Kiens B, Alsted TJ, Jeppesen J. Obes Rev, 2011
• Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling, Høeg LD, Sjøberg KA, Jeppesen J, Jensen TE, Frøsig C, Birk JB, Bisiani B, Hiscock N, Pilegaard H, Wojtaszewski JF, Richter EA, Kiens B. Diabetes, 2011

Fitness and Muscle 

Regulation of muscle substrate metabolism and insulin sensitivity: molecular mechanisms activated by exercise:

• Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release. Jensen TE, Sylow L, Rose AJ, Madsen AB, Angin Y, Maarbjerg SJ and Richter EA. Molecular Metabolism 2014.
• Acute mTOR inhibition induces insulin resistance and alters substrate utilization. Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxboll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA and Richter EA. Mol Metab 3: 630-641, 2014.
• Impairments in Site-Specific AS160 Phosphorylation and Effects of Exercise Training. Consitt LA, Van Meter J, Newton CA, Collier DN, Dar MS, Wojtaszewski JF, Treebak JT, Tanner CJ, Houmard JA. Diabetes. 2013 Oct.
• Exercise, GLUT4, and skeletal muscle glucose uptake. Richter EA, Hargreaves M. Physiol Rev. 2013 Jul.
• Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle. Mortensen B, Hingst JR, Frederiksen N, Hansen RW, Christiansen CS, Iversen N, Friedrichsen M, Birk JB, Pilegaard H, Hellsten Y, Vaag A, Wojtaszewski JF. Am J Physiol Endocrinol Metab. 2013 Jun.
• Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle. Sylow L, Jensen TE, Kleinert M, Højlund K, Kiens B, Wojtaszewski J, Prats C, Schjerling P, Richter EA. Diabetes. 2013 Jun.
• LKB1 regulates lipid oxidation during exercise independently of AMPK. Jeppesen J, Maarbjerg SJ, Jordy AB, Fritzen AM, Pehmøller C, Sylow L, Serup AK, Jessen N, Thorsen K, Prats C, Qvortrup K, Dyck JR, Hunter RW, Sakamoto K, Thomson DM, Schjerling P, Wojtaszewski JF, Richter EA, Kiens B. Diabetes. 2013 May.
• Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle. Sylow L, Jensen TE, Kleinert M, Mouatt JR, Maarbjerg SJ, Jeppesen J, Prats C, Chiu TT, Boguslavsky S, Klip A, Schjerling P, Richter EA. Diabetes. 2013 Apr.
• Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation. Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF. Am J Physiol Endocrinol Metab. 2013 Mar.
• Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. Kristensen JM, Larsen S, Helge JW, Dela F, Wojtaszewski JF. PLoS One. 2013.
• EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle. Jensen TE, Leutert R, Rasmussen ST, Mouatt JR, Christiansen ML, Jensen BR, Richter EA. PLoS One. 2012.
• Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes, Vind BF, Birk JB, Vienberg SG, Andersen B, Beck-Nielsen H, Wojtaszewski JF, Højlund K. Diabetologia, 2012
• GLUT4 and Glycogen Synthase Are Key Players in Bed Rest-Induced Insulin Resistance, Biensø RS, Ringholm S, Kiilerich K, Aachmann-Andersen NJ, Krogh-Madsen R, Guerra B, Plomgaard P, van Hall G, Treebak JT, Saltin B, Lundby C, Calbet JA, Pilegaard H, Wojtaszewski JF. Diabetes, 2012 
• Endurance Training Per Se Increases Metabolic Health in Young, Moderately Overweight Men, Nordby P, Auerbach PL, Rosenkilde M, Kristiansen L, Thomasen JR, Rygaard L, Groth R, Brandt N, Helge JW, Richter EA, Ploug T, Stallknecht B. Obesity (Silver Spring), 2012
• Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver, Haase TN, Ringholm S, Leick L, Biensø¸ RS, Kiilerich K, Johansen S, Nielsen MM, Wojtaszewski JF, Hidalgo J, Pedersen PA, Pilegaard H. Am J Physiol Regul Integr Comp Physiol, 2011
• Insulin Resistance after a 72 hour Fast is Associated with Impaired AS160 Phosphorylation and Accumulation of Lipid and Glycogen in Human Skeletal Muscle. Vendelbo MH, Clasen BF, Treebak JT, Møller L, Krusenstjerna-Hafstrøm T, Madsen M, Nielsen TS, Stødkilde-Jørgensen H, Pedersen SB, Jørgensen JO, Goodyear LJ, Wojtaszewski JF, Møller N, Jessen N. Am J Physiol Endocrinol Metab,2011
• Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle. Ringholm S, Biensø RS, Kiilerich K, Guadalupe-Grau A, Aachmann-Andersen NJ, Saltin B, Plomgaard P, Lundby C, Wojtaszewski JF, Calbet JA, Pilegaard H. Am J Physiol Endocrinol Metab, 2011
• Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle. Hunter RW, Treebak JT, Wojtaszewski JF, Sakamoto K. Diabetes, 2011
• Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signalling, Høeg LD, Sjøberg KA, Jeppesen J, Jensen TE, Frøsig C, Birk JB, Bisiani B, Hiscock N, Pilegaard H, Wojtaszewski JF, Richter EA, Kiens B. Diabetes, 2010
• Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training,Vind BF, Pehmøller C, Treebak JT, Birk JB, Hey-Mogensen M, Beck-Nielsen H, Zierath JR, Wojtaszewski JF, Højlund K. Diabetologia, 2011
• Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle, Frøsig C, Pehmøller C, Birk JB, Richter EA, Wojtaszewski JF. J Physiol, 2010
• PGC-1{alpha} Increases PDH Content But Does Not Change Acute PDH Regulation In Mouse Skeletal Muscle, Kiilerich K, Adser H, Jakobsen AH, Pedersen PA, Hardie DG, Wojtaszewski JF, Pilegaard H.Am J Physiol Regul Integr Comp Physiol, 2010

Molecular mechanisms defining the range of insulin sensitivity within the population at large:

• Endotrophin Triggers Adipose Tissue Fibrosis, Inflammation and Metabolic Dysfunction.Sun, K., Park, J., Gupta, O., Holland, W.L., Auerbach, P.L., Zhang, N., Marangoni, R.G., Nicoloro, S.M., Czech, M.P., Varga, J., Ploug, T., An, Z. and Scherer, P. E. Nat Commun. 2014 Mar
• Dose-response effects of endurance training on plasma adiponectin multimers in younger, moderately overweight men. Stallknecht, B., Auerbach, P.L., Reichkendler, M.H., Rosenkilde, M., Sjödin, A. and Ploug, T. Am J Physiol Regul Integr Comp Physiol. 2013 Sep

Metabolic and Cardiovascular health risks and benefits with profound changes in daily physical activity:

• The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training. Vigelsø A*, Andersen NB*, Dela F. Int J Physiol Pathophysiol Pharmacol. 12;6(2):84-101, 2014.
• Physical inactivity and muscle oxidative capacity in humans. Gram, M., R. Dahl, and F. Dela. Eur J Sport Sci, 2014. 14(4): p. 376-83.
• The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Larsen S, Danielsen JH, Sondergard SD, Sogaard D, Vigelsø A, Dybboe R, Skaaby S, Dela F, and Helge JW. Scandinavian journal of medicine & science in sports 2014. Scand J Med Sci Sports May 2014
• The effect of immobilization on exercise-induced interleukin-6 and tumor necrosis factor-&[alpha] release from the leg. Reihmane, D., Hansen A.V., Gram M., Kuhlman A.B., Nørregaard J., Pedersen H.P., Helge J.W., and Dela F. ExpPhysiol;98: 778-783, 2013.
• Human skeletal muscle perilipin 2 and 3 expression varies with insulin sensitivity. Vigelsø A, Prats C, Ploug T, Dela F, and Helge JW. Journal of Biomedical Science and Engineering, 2013 6: 65-72.
• Immobilisation increases interleukin-6, but not tumor necrosis factor-α, release from the leg during exercise in humans. Reihmane D, Hansen AV, Gram M, Kuhlman AB, Norregaard J, Pedersen HP, Lund MT, Helge JW and Dela F. Exp Physiol, 2013.
• Increased rate of whole body lipolysis before and after 9 days of bed rest in healthy young men born with low birth weight, Alibegovic AC, Højbjerre L, Sonne MP, van Hall G, Alsted TJ, Kiens B, Stallknecht B, Dela F, Vaag A. Am J Physiol Enocrinol Metab, 2010 

Dose-response effect of exercise training on metabolic health and appetite in overweight men:

• Calibrated Image Derived Input Functions for the Determination of the Metabolic Uptake Rate of Glucose with [18F]-FDG PET. Christensen, A.N., Reichkendler, M.H., Larsen, R., Auerbach, P.L., Hoejgaard, L., Nielsen, H.B., Ploug, T., Stallknecht, B. and Holm, S. Nucl Med Commun. 2014 Apr
• Biomarkers of coagulation, fibrinolysis, endothelial function, and inflammation in arterialized venous blood. Gram, A.S., Skov, J., Ploug, T., Sidelmann, J.J., Stallknecht, B.M. and Bladbjerg, E.M. Blood Coagul Fibrinolysis. 2014 Jan
• Changes in peak fat oxidation in response to different doses of endurance training. Rosenkilde, M., Reichkendler, M.H., Auerbach, P., Bonne, T.C., Sjödin, A., Ploug, T. and Stallknecht, B. Scand J Med Sci Sports. 2013 Dec
• Careful science? Bodywork and care practices in randomised clinical trials. Jespersen AP, Bønnelycke J and Eriksen HH. Sociology of health and illness, nov 6 2013.
• Appetite regulation in overweight, sedentary men after different amounts of endurance exercise - a randomized controlled trial. Rosenkilde M, Reichkendler MH, Auerbach P, Toräng S, Gram AS, Ploug T, Holst JJ, Sjödin A, Stallknecht BM. J Appl Physiol (1985). 2013 Sep.
• Compliance with physical exercise: Using a multidisciplinary approach within a dose-dependent exercise study of moderately overweight men. Gram AS, Bønnelycke J, Rosenkilde M, Reichkendler M, Auerbach P, Sjödin A, Ploug T, Jespersen A, Stallknecht B. Scand J Public Health. 2013 Sep.
• Exercise training favors increased insulin-stimulated glucose uptake in skeletal muscle in contrast to adipose tissue: A randomized study using FDG PET imaging.Reichkendler, M., Auerbach P, Rosenkilde M, Christensen A, Holm S, Petersen MB, Lagerberg A, Larsson H, Rostrup E, Mosbech T, Sjödin A, Kjær A, Ploug T, Højgaard L, and Stallknecht BM. Am.J.Physiol.Endocrinol.Metab., Aug 2013.
• Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. Auerbach, P, Nordby P, Bendtsen LQ, Mehlsen JL, Basnet SK, Vestergaard H, Ploug T, and Stallknecht BM. Am.J.Physiol.Regul.Integr. Comp.Physiol., Sep 2013.
• Only minor metabolic health benefits of high as opposed to moderate dose physical exercise in young, moderately overweight men. Reichkendler M H, Rosenkilde M, Auerbach PL, Agerschou J, Nielsen MB, Kjaer A, Hoejgaard L, Sjödin A, Ploug T and Stallknecht B. Obesity, Dec. 2012
• Effect of Different Doses of Exercise on Sleep Duration, Sleep Efficiency and Sleep Quality in Sedentary, Overweight Men. Kjeldsen JS, Rosenkilde M, Nielsen SW, Reichkendler M, Auerbach P, Ploug T, Stallknecht B, Sjödin A and Chaput J-P. Bioenergetics, Oct. 2012
• Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise - a randomized controlled trial in overweight sedentary males. Rosenkilde M, Auerbach P, Reichkendler MH, Ploug T, Stallknecht BM, Sjödin A. Am J Physiol Regul Integr Comp Physiol, 2012
• Endurance Training Per Se Increases Metabolic Health in Young, Moderately Overweight Men, Nordby P, Auerbach PL, Rosenkilde M, Kristiansen L, Thomasen JR, Rygaard L, Groth R, Brandt N, Helge JW, Richter EA, Ploug T, Stallknecht B. Obesity (Silver Spring), 2012
• Kroppe i laboratoriet. Individuelle kroppe, forsøgskroppe og samfundskroppe i kliniske forsøg med overvægt. Astrid Pernille Jespersen. Kulturstudier, 2011

Endurance training, psychosocial intervention, gut hormones and glucose tolerance:

• Examining the Effects of Hyperglycaemia on Pancreatic Endocrine Function in Humans: Evidence for in Vivo Glucotoxicity. Solomon TP et al. J Clin Endocrinol Metab, 2012
• Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men. Knudsen SH, Hansen LS, Pedersen M, Dejgaard T, Hansen J, Hall GV, Thomsen C, Solomon TP, Pedersen BK, Krogh-Madsen R. J Appl Physiol, 2012
• Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia. Green CJ et al. PLoS One, 2012
• Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle. Bouzakri K, Plomgaard P, Berney T, Donath MY, Pedersen BK, Halban PA. Diabetes, Apr 2011
• Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event. Laye MJ, Solomon TP, Karstoft K, Pedersen KK, Nielsen SD, Pedersen BK. J Appl Physiol, 2011 
• Exercise-induced myokines and their role in chronic diseases, Pedersen BK. Brain Behav Immun, 2011
• Exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine, Hansen J, Brandt C, Nielsen AR, Hojman P, Whitham M, Febbraio MA, Pedersen BK, Plomgaard P Endocrinology, 2011
• Exercise-induced liver chemokine CXCL-1 expression is linked to muscle derived IL-6 expression, Pedersen L et al. J Physiol, 2011
• A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. Krogh-Madsen R, Thyfault JP, Broholm C, Mortensen OH, Olsen RH, Mounier R, Plomgaard P, van Hall G, Booth FW, Pedersen BK. J Appl Physiol, 2010

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Publications within Social Sciences and Humanities

Eating practices: Social and cultural aspects of hunger and satiety:

• Social class and body management. A qualitative exploration of differences in perceptions and practices related to health and personal body weight. Smith LH and Holm L. Appetite, 2010

Changing discourses and strategies in the fight against life-style related diseases:

• Should we Hold the Obese Responsible? Some Key Issues. Nielsen MEJ and Andersen MM. Cambridge Quarterly of Healthcare Ethics 2013.
• Bioethics in Denmark. Nielsen MEJ and Andersen MM. Cambridge Quarterly of Healthcare Ethics 2013.
• Obesity as a showcase for transdisciplinary research. Holm L, Børker Nielsen P, Sandøe P, Juul Nielsen ME. Obes Facts. 2013.
• Is it acceptable to use animals to model obese humans? – A critical discussion of two arguments against the use of animals in obesity research. Lund TB, Sørensen TI, Olsson IA, Hansen AK and Sandøe P.J Med Ethics, 2013
• Should we equalize status in order to equalize health? Nielsen MEJ Marchman M and Landes X. Public Health Ethics, 2013
• Nudge: A new and better way to improve health? Vallgårda S. Health Policy, 2012
• Attitudes to publicly funded obesity treatment and prevention,Lund TB, Sandøe P, Lassen J. Obesity (Silver Spring), 2011
• The ethnics of prevention, Vallgårda S. Bibl Læger, 2011
• Why the concept ‘‘lifestyle diseases'' should be avoided, Vallgårda S. Scand J Public Health, 2011
• Addressing individual behaviours and living conditions: Four Nordic public health policies, Vallgårda S. Scand J Public Health, 2011
• Appeals to autonomy and obedience. Continuity and change in governing technologies in health promotion, Vallgårda S. Med Hist, 2011
• Republicanism as a Paradigm for Public Health - Some Comments, Nielsen MEJ. Public Health Ethics, 2011
• Prioritering og social retfærdighed. I Størup et al (red): Det sunde valg, Nielsen MEJ. Sundhedsstyrelsen, 2010
• Is the focus on health-related behaviours a new phenomenon? Vallgårda S. Social Studies of Science, 2010

(Un)healthy bodies – health discourses and physical (in)activity among Danish adults: 

• Are young people caught in the time bind? A sociological analysis of how young people in an upper secondary school view the issue of finding time to do sports or exercise in their spare time. Friis Thing L, Frydendal Nielsen S & Ottesen L, Annals of Leisure Research2014
• Young people's perspectives on health, risks and physical activity in a Danish secondary school. Friis Thing L & Ottesen L. Health, Risk & Society, 2013
• Ida spielt ihr eigenes Spiel - "doing gender" im Sportunterricht', Pfister G, With-Nielsen N. Spectrum der Sportwissenschaften, 2010
• Unges syn på idræt, bevægelse og sundhed i gymnasieskolen. En kvantitativ undersøgelse af Rysensteen Gymnasium. Nielsen SF Brandt-Hansen M, Nielsen G, Ottesen L og Thing LF. Københavns Universitet, 2011.
• Åbne fodboldbaner i dagtimerne. Igangsættelse af motionstiltag for inaktive grupper: Hvidbog om sundhedsfremme i kommunalt regi, Krustrup BR Nielsen SF & Ottesen L. Københavns Universitet, 2011.
• The development of social capital through soccer and running: The experience of a 16 weeks intervention programme for inactive, inexperienced women. Ottesen L, Jeppesen R and Krustrup B. Scand J Med Sci Sports, 2010

Public and market regulation in the fight against life-style diseases – Opportunities and barriers:

• Stigmatisation as a Public Health Tool against Obesity – A Health and Human Rights Perspective. Hartlev M. European Journal of Health Law 21 (2014), pp. 365-386.
• Obesity and industry self-regulation of food and beverage marketing: a literature review. Ronit K, Jensen JD. Eur J Clin Nutrition April 2014.
• The Danish tax on saturated fat – Short run effects on consumption, substitution patterns and consumer prices of fats. Dejgård Jensen J & Smed S. Food Policy, Volume 42, October 2013
• Food Industry Firms' Economic Incentives to Provide Nutritional Information to the Market: European Breakfast Cereals, Snacks, and Soft Drinks Industries, Jensen JD & Ronit K. Journal of International Food & Agribusiness Marketing, 2013
• Healthy Ageing — A Patients' Rights Perspective, Hartlev M. European Journal of Health Law, 2012
• Obesity in Europe: The Strategy of the European Union from a Public Health Law Perspective, Faeh A. European Journal of Health Law, 2012

Social-Psychological Interventions and Experiments for Effective Life Style Changes:

• Qualitative research building real-life interventions: user-involving development of a mindfulness-based lifestyle change support program for overweight citizens. Hansen NV, Brændgaard P, Hjørnholm C, la Cour S. Eur J Clin Nutr. 2014 Jun

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Publications within Genetic Epidemiology

Studies of metabolic and cardiovascular health genetics and the interaction with health behaviour and socioeconomics in the DCH cohort based upon LuCAMP derived exome discoveries:

• FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals. Qi, Q Kilpeläinen T, Downer MK et al
• Pleiotropic genes for metabolic syndrome and inflammation. Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, Morris A, Pendergrass SA, Sun YV, Ritchie MD, Vaez A, Lin H, Ligthart S, Marullo L, Rohde R, Shao Y, Ziegler MA, Im HK, Cross Consortia Pleiotropy (XC-Pleiotropy) Group, the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE), the Genetic Investigation of Anthropometric Traits (GIANT) Consortium, the Global Lipids Genetics Consortium (GLGC), the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), the Global BPgen (GBPG) Consortium, The ADIPOGen Consortium, the Women’s Genome Health Study (WGHS), the Howard University Family Study (HUFS), Schnabel RB, Jørgensen T, Jørgensen ME, Hansen T, Pedersen O, Stolk RP, Snieder H, Hofman A, Uitterlinden AG, Franco OH, Ikram MA, Richards JB, Rotimi C, Wilson JG, Lange L, Ganesh SK, Nalls M, Rasmussen-Torbik LJ, Pankow JS, Coresh J, Tang W, Kao WHL, Boerwinkle E, Morrison AC, Ridker PM, Becker DM, Rotter JI, Kardia SLR, Loos RJF, Larson MG, Hsu YH, Province MA, Tracy R, Voight BF, Vaidya D, O’Donnell C, Benjamin EJ, Alizadeh BZ, Prokopenko I, Meigs JB, Borecki IB. Mol Genet Metab 2014 [in press]
• Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Lohmueller KE, Sparsø T, Li Q, Andersson E, Korneliussen T, Albrechtsen A, Banasik K, Grarup N, Hallgrimsdottir I, Kiil K, Kilpeläinen TO, Krarup NT, Pers TH, Sanchez G, Hu Y, Degiorgio M, Jørgensen T, Sandbæk A, Lauritzen T, Brunak S, Kristiansen K, Li Y, Hansen T, Wang J, Nielsen R, Pedersen O. Am J Hum Genet 2013;93:1072-86.
• Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. Grarup N, Sulem P, Sandholt CH, Thorleifsson G, Ahluwalia TS, Steinthorsdottir V, Bjarnason H, Gudbjartsson DF, Magnusson OT, Sparsø T, Albrechtsen A, Kong A, Masson G, Tian G, Cao H, Nie C, Kristiansen K, Husemoen LL, Thuesen B, Li Y, Nielsen R, Linneberg A, Olafsson I, Eyjolfsson GI, Jørgensen T, Wang J, Hansen T, Thorsteinsdottir U, Stefánsson K, Pedersen O. PLoS Genet. 2013 Jun.
• Roswall N, Halkjær J, Overvad K, Tjønneland A. Measures taken to restore the Danish Diet, Cancer and Health biobank after flooding: A framework for future biobank restorations. Biopreservation and Biobanking. 2013;11:206-10
• Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY, Korneliussen T, Li Q, Nie C, Wu R, Skotte L, Morris AP, Ladenvall C, Cauchi S, Stančáková A, Andersen G, Astrup A, Banasik K, Bennett AJ, Bolund L, Charpentier G, Chen Y, Dekker JM, Doney AS, Dorkhan M, Forsen T, Frayling TM, Groves CJ, Gui Y, Hallmans G, Hattersley AT, He K, Hitman GA, Holmkvist J, Huang S, Jiang H, Jin X, Justesen JM, Kristiansen K, Kuusisto J, Lajer M, Lantieri O, Li W, Liang H, Liao Q, Liu X, Ma T, Ma X, Manijak MP, Marre M, Mokrosiński J, Morris AD, Mu B, Nielsen AA, Nijpels G, Nilsson P, Palmer CN, Rayner NW, Renström F, Ribel-Madsen R, Robertson N, Rolandsson O, Rossing P, Schwartz TW; D.E.S.I.R. Study Group, Slagboom PE, Sterner M; DIAGRAM Consortium, Tang M, Tarnow L, Tuomi T, van't Riet E, van Leeuwen N, Varga TV, Vestmar MA, Walker M, Wang B, Wang Y, Wu H, Xi F, Yengo L, Yu C, Zhang X, Zhang J, Zhang Q, Zhang W, Zheng H, Zhou Y, Altshuler D, 't Hart LM, Franks PW, Balkau B, Froguel P, McCarthy MI, Laakso M, Groop L, Christensen C, Brandslund I, Lauritzen T, Witte DR, Linneberg A, Jørgensen T, Hansen T, Wang J, Nielsen R, Pedersen O. Diabetologia. 2013 Feb.
• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution, Heid IM et al. Nat Genet, 2010
• Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants, Li Y, Vinckenbosch N, Tian G, Huerta-Sanchez E, Jiang T, Jiang H, Albrechtsen A, Andersen G, Cao H, Korneliussen T, Grarup N, Guo Y, Hellman I, Jin X, Li Q, Liu J, Liu X, Sparsø T, Tang M, Wu H, Wu R, Yu C, Zheng H, Astrup A, Bolund L, Holmkvist J, Jørgensen T, Kristiansen K, Schmitz O, Schwartz TW, Zhang X, Li R, Yang H, Wang J, Hansen T, Pedersen O, Nielsen R and Wang J. Nat Genet, 2010
• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Speliotes EK et al. incl Loos RJ. Nat Genet, 2010
• A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B, Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S, Ng DP, Ma RC, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jørgensen T, Lauritzen T, Sandbæk A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JC, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwagi A, Kawamori R, Kasuga M, Froguel P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T. Nat Genet, 2010
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis, Voight BF et al. Nat Genet, 2010

Genes interacting with dietary factors in determining body weight changes and eventual development of obesity:

• Being an only or last-born child increases later risk of obesity. Haugaard LK, Ajslev TA, Zimmermann E, Angquist L, Sørensen TI. PLoS One, Epub Feb 2013
• TFAP2B -Dietary Protein and Glycemic Index Interactions and Weight Maintenance after Weight Loss in the DiOGenes Trial. Stocks T, Angquist L, Hager J, Charon C, Holst C, Martinez JA, Saris WH, Astrup A, Sørensen TI, Larsen LH. Hum Hered. 2013.
• TFAP2B influences the effect of dietary fat on weight loss under energy restriction. Stocks T, Angquist L, Banasik K, Harder MN, Taylor MA, Hager J, Arner P, Oppert JM, Martinez JA, Polak J, Rousseau F, Langin D, Rössner S, Holst C, MacDonald IA, Kamatani Y, Pfeiffer AF, Kunesova M, Saris WH, Hansen T, Pedersen O, Astrup A, Sørensen TI. PLoS One, 2012
• Assortative marriages by body mass index have increased simultaneously with the obesity epidemic. Ajslev TA, Angquist L, Silventoinen K, Gamborg M, Allison DB, Baker JL, Sørensen TI. Front Genet, 2012
• Modifiable environmental influences on body mass index shared by young adult brothers. Rokholm B, Silventoinen K, Tynelius P, Sørensen TI, Rasmussen F. Int J Obes (Lond), 2012
• Dietary factors impact on the association between CTSS variants and obesity related traits. Hooton H, Angquist L, Holst C, Hager J, Rousseau F, Hansen RD, Tjønneland A, Roswall N, van der A DL, Overvad K, Jakobsen MU, Boeing H, Meidtner K, Palli D, Masala G, Bouatia-Naji N, Saris WH, Feskens EJ, Wareham NJ, Vimaleswaran KS, Langin D, Loos RJ, Sørensen TI, Clément K. PLoS One, 2012
• Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study. Larsen LH, Angquist L, Vimaleswaran KS, Hager J, Viguerie N, Loos RJ, Handjieva-Darlenska T, Jebb SA, Kunesova M, Larsen TM, Martinez JA, Papadaki A, Pfeiffer AF, van Baak MA, Sørensen TIa, Holst C, Langin D, Astrup A, Saris WH. Am J Clin Nutr, 2012
• Increasing Genetic Variance of Body Mass Index during the Swedish Obesity Epidemic. Rokholm B, Silventoinen K, Tynelius P, Gamborg M, Sørensen TIA, Rasmussen F. PLoS One, 2011
• Food composition of the diet in relation to changes in waist circumference adjusted for body mass index. Romaguera D, Ängquist L, Du H, Jakobsen MU, Forouhi NG, Halkjær J, Feskens EJ, van der A DL, Masala G, Steffen A, Palli D, Wareham NJ, Overvad K, Tjønneland A, Boeing H, Riboli E, Sørensen TI. PLoS One, 2011
• Increased genetic variance of BMI with a higher prevalence of obesity. Rokholm B, Silventoinen K, Ängquist L, Skytthe A, Kyvik KO, Sørensen TI. PLoS One, 2011
• Genetic polymorphisms in the hypothalamic pathway in relation to subsequent weight change--the DiOGenes study. Du H, Vimaleswaran KS, Angquist L, Hansen RD, van der A DL, Holst C, Tjønneland A, Overvad K, Jakobsen MU, Boeing H, Meidtner K, Palli D, Masala G, Bouatia-Naji N, Saris WH, Feskens EJ, Wareham NJ, Sørensen TI, Loos RJ. PLoS One, 2011
• The levelling off of the obesity epidemic since the year 1999-a review of evidence and perspectives. Rokholm B, Baker JL, Sørensen TI. Obes Rev, 2010
• Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity. Romaguera D, Angquist L, Du H, Jakobsen MU, Forouhi NG, Halkjaer J, Feskens EJ, van der A DL, Masala G, Steffen A, Palli D, Wareham NJ, Overvad K, Tjønneland A, Boeing H, Riboli E, Sørensen TI. PLoS One, 2010
• MTNR1B G24E variant associates with BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans, Andersson EA, Holst B, Sparsø T, Grarup N, Banasik K, Holmkvist J, Jørgensen T, Borch-Johnsen K, Egerod KL, Lauritzen T, Sørensen TI, Bonnefond A, Meyre D, Froguel P, Schwartz TW, Pedersen O, Hansen T. Diabetes, 2010

Studies of metabolic and cardiovascular health genetics: Establishment of a pig resource population:

• Systems genetics of obesity in an F2 pig model by genome-wide association, genetic network and pathway analyses. Lisette Kogelman ; Sameer Dinkar Pant ; Merete Fredholm ; Haja Kadarmideen. Frontiers in Genetics, section Systems Biology, Vol. 5, 07.2014, s. 214.
• Expression studies of six human obesity-related genes in seven tissues from divergent pig breeds. Cirera S, Jensen MS, Elbrønd VS, Moesgaard SG, Christoffersen BO, Kadarmideen HN, Skovgaard K, Bruun CV, Karlskov-Mortensen P, Jørgensen CB, Fredholm M. Anim Genet. 2013 Aug.
• An f2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters. Kogelman LJ, Kadarmideen HN, Mark T, Karlskov-Mortensen P, Bruun CS, Cirera S, Jacobsen MJ, Jørgensen CB, Fredholm M. Front Genet, 2013

All publications originated from grants given by UNIK have the following reference in a footnote, on the frontispiece, or at the end of the paper:

"This work is carried out as a part of the research program of the UNIK: Food, Fitness & Pharma for Health and Disease (see www.foodfitnesspharma.ku.dk). The UNIK project is supported by the Danish Ministry of Science, Technology and Innovation"